Gt(ROSA)26Sor^{tm1(CAG-F2r*)H}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-F2r*)H}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Harwell
• MGI ID: MGI:7658890
• Synonyms: Gt(ROSA)26Sor^F2r*
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-F2r*)H} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:349842
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This insert encodes a CAG promoter proceeded by a floxed stop cassette driving expression of a transgenic form of the F2r (PAR-1) receptor that is phospho-null at the C-terminus. As such the normal signaling that leads to the activated form of the receptor being degraded can not function. Once activated the mutant form of the receptor remains at the membrane and continues to signal. (J:349842)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:349842 May CJ, et al., Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events. Kidney Int. 2023 Aug;104(2):265-278
• All: 1 reference(s)