Fto^em1H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fto^em1H
• Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1, Harwell
• MGI ID: MGI:7658874
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^em1H page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 82 bp deleting rs14210855, a cis regulatory module in adenocyte progenitors and highly conserved ARID 5B TFBS Motif (DNA Binding domain). (J:349711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 76 strains or lines available

References

• Original: J:349711 Laber S, et al., Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo. Sci Adv. 2021 Jul;7(30)
• All: 1 reference(s)