Pik3c2a^tm2Bvan
Targeted Allele Detail

Summary

• Symbol: Pik3c2a^tm2Bvan
• Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; targeted mutation 2, Bart Vanhaesebroeck
• MGI ID: MGI:7657347
• Synonyms: PI3K-C2a-flox
• Gene: Pik3c2a Location: Chr7:115936500-116042684 bp, - strand Genetic Position: Chr7, 61.62 cM
• Alliance: Pik3c2a^tm2Bvan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exons 24 and 25. Cre-mediated recombination results in in-frame deletion of motifs essential for catalytic activity and the expression of an internally truncated kinase-dead protein with reduced stability. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3c2a Mutation: 100 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 2 reference(s)