Pcsk9^{tm1(PCSK9)Cya}
Targeted Allele Detail

Summary

• Symbol: Pcsk9^{tm1(PCSK9)Cya}
• Name: proprotein convertase subtilisin/kexin type 9; targeted mutation 1, Cyagen Biosciences
• MGI ID: MGI:7657307
• Synonyms: Pcsk9^{tm1(hPCSK9)Cya}
• Gene: Pcsk9 Location: Chr4:106299531-106321522 bp, - strand Genetic Position: Chr4, 49.67 cM
• Alliance: Pcsk9^{tm1(PCSK9)Cya} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Pcsk9^{tm1(PCSK9)Cya} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PCSK9 (255738)

  Pcsk9

  (MGI:2140260)

• Mutation details: The mouse Pcsk9 gene sequence, including ~35.5kb upstream and ~7kb downstream sequences, was replaced with the corresponding sequences in the human PCSK9 gene, including the untranslated regions(UTRs). (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcsk9 Mutation: 45 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)