Il15^em2(IL15)Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il15^em2(IL15)Cya
• Name: interleukin 15; endonuclease-mediated mutation 2, Cyagen Biosciences
• MGI ID: MGI:7657280
• Synonyms: Il15^{em1(hIL15)Cya}
• Gene: Il15 Location: Chr8:83058261-83129851 bp, - strand Genetic Position: Chr8, 39.33 cM
• Alliance: Il15^em2(IL15)Cya page

Mutation origin

• Strain of Origin: NOD.Cg-Prkdc^scid/Cya

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Il15^em2(IL15)Cya expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL15 (3600)

  Il15	(MGI:103014)

• Mutation details: The NKG-hIL15 mice are constructed by knocking in the human IL15 gene from the NKG mice. Compared to NKG mice, NKG-hIL15 mice significantly enhance the reconstitution proportion of human NK cells after HSC or PBMC transplantation. These mice can be utilized for the development of immunotherapies targeting NK cells and drug evaluation. (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il15 Mutation: 44 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)