Cd274^{em1(CD274)Cya}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cd274^{em1(CD274)Cya}
• Name: CD274 antigen; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7657222
• Synonyms: Cd274^{em1(hCD274 IgV-like)}
• Gene: Cd274 Location: Chr19:29344855-29365495 bp, + strand Genetic Position: Chr19, 23.88 cM, cytoband C2
• Alliance: Cd274^{em1(CD274)Cya} page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cd274^{em1(CD274)Cya} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD274 (29126)

  Cd274

  (MGI:1926446)

• Mutation details: The gene sequence encoding the extracellular domain (immunoglobulin V-like, IgV-like) of mouse PD-L1 protein is replaced with the corresponding human PD-L1 gene sequence, while the sequence encoding the signal peptide is retained. (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd274 Mutation: 71 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)