Apc^em3Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Apc^em3Cya
• Name: APC, WNT signaling pathway regulator; endonuclease-mediated mutation 3, Cyagen Biosciences
• MGI ID: MGI:7657210
• Synonyms: Apc^em2Cya
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^em3Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The Apc gene is located on chromosome 18 in mice and contains a total of 16 exons. Gene editing technology is used to knock out a portion of the exon 16 of this gene. This exon occupies more than 70% of the coding region of the Apc gene and includes the mutation cluster region (MCR) corresponding to high-frequency mutations in human diseases. This strain is homozygous lethal. Heterozygous Apc KO mice can spontaneously develop intestinal adenomas and exhibit significant colorectal cancer disease phenotypes in various aspects such as survival, growth, food intake, and intestinal lesions. Therefore, Apc KO mice can be used for familial adenomatous polyposis (FAP) and colorectal cancer and other tumors or tumor-related diseases, as well as the study of the regulatory mechanism of the Wnt/-catenin signaling pathway. (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 156 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)