Ace2^em7(ACE2)Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em7(ACE2)Cya
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 7, Cyagen Biosciences
• MGI ID: MGI:7657204
• Synonyms: Ace2^{em2(hACE2-P2A-EGFP)}
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em7(ACE2)Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Ace2^em7(ACE2)Cya expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Mutation details: The endogenous Ace2 gene sequence of the mouse was replaced with the coding sequence (CDS) of the human ACE2 gene while retaining the sequence encoding the mouse ACE2 protein signal peptide. In addition, an enhanced green fluorescent protein (EGFP) expression cassette was inserted into the model to allow tracking of hACE2 expression. (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 71 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)