Ing4^tm1.2Avo
Targeted Allele Detail

Summary

• Symbol: Ing4^tm1.2Avo
• Name: inhibitor of growth family, member 4; targeted mutation 1.2, Anne K Voss
• MGI ID: MGI:7643770
• Synonyms: Ing4^-
• Gene: Ing4 Location: Chr6:125016811-125026228 bp, + strand Genetic Position: Chr6, 59.17 cM
• Alliance: Ing4^tm1.2Avo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:346139
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 6 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 3 - 6. Quantitative RT-PCR confirmed the absence of RNA in homozygous embryos. (J:346139)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ing4 Mutation: 34 strains or lines available

References

• Original: J:346139 Mah SYY, et al., ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development. Development. 2024 Mar 1;151(5):dev202617
• All: 1 reference(s)