Tg(Thy1-SNCA*)G51DNuber
Transgene Detail

Summary

• Symbol: Tg(Thy1-SNCA*)G51DNuber
• Name: transgene insertion G51D, Silke Nuber
• MGI ID: MGI:7643545
• Synonyms: Tg(Thy1-SNCA*)1Dett, Thy1-G51D
• Transgene: Tg(Thy1-SNCA*)G51DNuber Location: unknown
• Alliance: Tg(Thy1-SNCA*)G51DNuber page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-SNCA*)G51DNuber expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Tg(Thy1-SNCA*)G51DNuber expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Thy1 (MGI:98747)

• Mutation details: Full-length human SCNA cDNA was mutagenized to carry a G51D mutation (nucleotide change: GGT to GAT in exon 3) and placed under the control of the mouse Thy1 neuronal promoter. (J:348676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:348676 Nuber S, et al., Generation of G51D and 3D mice reveals decreased alpha-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinsons Dis. 2024;10(1)
• All: 1 reference(s)