Otud7a^em1Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Otud7a^em1Tcp
• Name: OTU domain containing 7A; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:7639952
• Synonyms: 3XFLAG-Otud7a
• Gene: Otud7a Location: Chr7:63094499-63408776 bp, + strand Genetic Position: Chr7, 34.52 cM
• Alliance: Otud7a^em1Tcp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to insert a 3XFLAG tag and GGSG flexible linker immediately after the start codon. An upstream intronic variant (1-bp delG Chr7:63650782 (GRCm38) was also identified after generation of the mutant allele. (J:348102)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otud7a Mutation: 37 strains or lines available

References

• Original: J:348102 Unda BK, et al., Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Mol Psychiatry. 2023 Apr;28(4):1747-1769
• All: 1 reference(s)