Fbxo24^em1Syu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxo24^em1Syu
• Name: F-box protein 24; endonuclease-mediated mutation 1, Shuiqiao Yuan
• MGI ID: MGI:7628680
• Gene: Fbxo24 Location: Chr5:137610767-137623340 bp, - strand Genetic Position: Chr5, 76.59 cM, cytoband G1
• Alliance: Fbxo24^em1Syu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs created an 82 bp deletion in exon 3. qPCR analysis found that mRNA expression was almost undetectable in testes from homozygous mice. (J:347878)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxo24 Mutation: 77 strains or lines available

References

• Original: J:347878 Li Z, et al., FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility. Elife. 2024 Mar 12;12
• All: 1 reference(s)