Clcn5^em1Oawe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clcn5^em1Oawe
• Name: chloride channel, voltage-sensitive 5; endonuclease-mediated mutation 1, Ora Weisz
• MGI ID: MGI:7628400
• Synonyms: ClC-5 KO
• Gene: Clcn5 Location: ChrX:7020049-7185597 bp, - strand Genetic Position: ChrX, 3.21 cM, cytoband F3-F4
• Alliance: Clcn5^em1Oawe page

Mutation origin

• Strain of Origin: 129S2/SvPasCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, an 189 bp that includes half of exon 6 and the intron junction of the Clcn5 gene was deleted. This mutation prevents splicing of intron 6 resulting in the knock-out of Clcn5. (J:347887)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clcn5 Mutation: 16 strains or lines available

References

• Original: J:347887 Shipman KE, et al., Impaired Endosome Maturation Mediates Tubular Proteinuria in Dent Disease Cell Culture and Mouse Models. J Am Soc Nephrol. 2023 Apr 1;34(4):619-640
• All: 2 reference(s)