Tg(CMV-IL2/IL15)1-1Jic
Transgene Detail

Summary

• Symbol: Tg(CMV-IL2/IL15)1-1Jic
• Name: transgene insertion 1-1, Central Institute for Experimental Animals, Japan
• MGI ID: MGI:7623211
• Synonyms: Tg(CMV-IL15)1Jic
• Transgene: Tg(CMV-IL2/IL15)1-1Jic Location: unknown
• Alliance: Tg(CMV-IL2/IL15)1-1Jic page

Transgene origin

• Strain of Origin: NOD.129-Il2rg^tm1Sug

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-IL2/IL15)1-1Jic expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL15 (3600)

  Il15	(MGI:103014)

• Tg(CMV-IL2/IL15)1-1Jic expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cytomegalovirus	CMV

• Mutation details: Under the control of a CMV promoter, this transgene expresses a human IL-15 cDNA, whose signal peptide sequence was replaced with that of the human IL-2 gene for improving secretion. (J:287514)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:287514 Katano I, et al., Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse. Sci Rep. 2017 Dec 8;7(1):17230
• All: 2 reference(s)