Gt(ROSA)26Sorem1(CAG-Sting1*)Jmin
Endonuclease-mediated Allele Detail
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Symbol: |
Gt(ROSA)26Sorem1(CAG-Sting1*)Jmin |
Name: |
gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Jonathan Miner |
MGI ID: |
MGI:7621479 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sorem1(CAG-Sting1*)Jmin page
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Allele Type: |
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Endonuclease-mediated (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sorem1(CAG-Sting1*)Jmin expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Sting1 (MGI:1919762) |
(N153S; AAT to TCT) humanized sequence |
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Mutation details: A CAG::loxP::transcriptional stop sequence::loxP::STING*N153S cassette was introduced to the mouse Gt(ROSA)26Sor gene using transcription activator-like effector nucleases (TALENs). The STING N153S mutation incorporates a AAT to TCT nucleotide change in exon 5 that results in an amino acid substitution at position 153. The STING N153S mutation is analogous to the N154S mutation in human TMEM173. N154S is associated with (STING)-associated vasculopathy with onset in infancy (SAVI).
(J:291925)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
956 strains or lines available
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Original: |
J:291925 Bennion BG, et al., STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice. Cell Rep. 2020 Jun 16;31(11):107771 |
All: |
1 reference(s) |
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