Gt(ROSA)26Sor^{em1(CAG-Sting1*)Jmin}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Sting1*)Jmin}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Jonathan Miner
• MGI ID: MGI:7621479
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Sting1*)Jmin} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-Sting1*)Jmin} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sting1 (MGI:1919762)	(N153S; AAT to TCT) humanized sequence

• Mutation details: A CAG::loxP::transcriptional stop sequence::loxP::STING*N153S cassette was introduced to the mouse Gt(ROSA)26Sor gene using transcription activator-like effector nucleases (TALENs). The STING N153S mutation incorporates a AAT to TCT nucleotide change in exon 5 that results in an amino acid substitution at position 153. The STING N153S mutation is analogous to the N154S mutation in human TMEM173. N154S is associated with (STING)-associated vasculopathy with onset in infancy (SAVI). (J:291925)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:291925 Bennion BG, et al., STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice. Cell Rep. 2020 Jun 16;31(11):107771
• All: 3 reference(s)