Hsd3b6^tm1.1Hokh
Targeted Allele Detail

Summary

• Symbol: Hsd3b6^tm1.1Hokh
• Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6; targeted mutation 1.1, Hitoshi Okamura
• MGI ID: MGI:7621193
• Synonyms: Hsd3b6^fl, Hsd3b6^fx
• Gene: Hsd3b6 Location: Chr3:98712820-98721759 bp, - strand Genetic Position: Chr3, 42.88 cM
• Alliance: Hsd3b6^tm1.1Hokh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:347048
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and an FRT-flanked neomycin selection cassette was inserted downstream of the second loxP site. The neomycin selection cassette was removed via cre-mediated recombination, leaving exon 2 floxed. (J:347048)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd3b6 Mutation: 21 strains or lines available

References

• Original: J:347048 Sasaki L, et al., Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction. Nat Aging. 2022 Feb;2(2):105-114
• All: 1 reference(s)