Mir204^tm1.1Kpal
Targeted Allele Detail

Summary

• Symbol: Mir204^tm1.1Kpal
• Name: microRNA 204; targeted mutation 1.1, Krzysztof Palczewski
• MGI ID: MGI:7620423
• Gene: Mir204 Location: Chr19:22727969-22728036 bp, + strand Genetic Position: Chr19, 17.26 cM
• Alliance: Mir204^tm1.1Kpal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:353034
• Parent Cell Line: iTL BF1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert two loxP sites flanking the microRNA-204 (Mir204) sequence within the intron of the transient receptor potential cation channel, subfamily M, member 3 (Trpm3) gene. The targeting construct also included an FRT-flanked neomycin cassette. Transient transfection with Flp recombinase excised the neomycin resistance cassette. (J:101977, J:353034)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir204 Mutation: 6 strains or lines available

References

• Original: J:353034 Du SW, et al., Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration. J Biol Chem. 2024 May 4;300(6):107344
• All: 2 reference(s)