Tff2^tm1.1Htk
Targeted Allele Detail

Summary

• Symbol: Tff2^tm1.1Htk
• Name: trefoil factor 2 (spasmolytic protein 1); targeted mutation 1.1, Hsun Teresa Ku
• MGI ID: MGI:7620295
• Synonyms: Tff2^fl
• Gene: Tff2 Location: Chr17:31360036-31363256 bp, - strand Genetic Position: Chr17, 15.8 cM
• Alliance: Tff2^tm1.1Htk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:353482
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were flanked by loxP sites and an frt-flanked neomycin selection cassette. Flp-mediated recombination removed the selection cassette.

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tff2 Mutation: 11 strains or lines available

References

• Original: J:353482 Ortiz JA, et al., Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for beta-Cell Function During Aging. Diabetes. 2024 Sep 1;73(9):1447-1461
• All: 1 reference(s)