Trim24^em1Schen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim24^em1Schen
• Name: tripartite motif-containing 24; endonuclease-mediated mutation 1, Shuai Chen
• MGI ID: MGI:7614463
• Synonyms: TRIM24^C52/55A
• Gene: Trim24 Location: Chr6:37847746-37943231 bp, + strand Genetic Position: Chr6, 17.07 cM, cytoband B1
• Alliance: Trim24^em1Schen page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Cysteine codons 52 (TGC) and 55 (TGC) in exon 1 were changed to alanine (GCA) (p.C52A, p.C55A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutations, in the RING E3-ligase domain of the encoded peptide, render the peptide ligase-dead. (J:345293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim24 Mutation: 98 strains or lines available

References

• Original: J:345293 Wei W, et al., TRIM24 is an insulin-responsive regulator of P-bodies. Nat Commun. 2022 Jul 8;13(1):3972
• All: 1 reference(s)