Tg(CAG-H3-3B*K37M)1Kaig
Transgene Detail

Summary

• Symbol: Tg(CAG-H3-3B*K37M)1Kaig
• Name: transgene insertion 1, Kai Ge
• MGI ID: MGI:7612329
• Synonyms: LSL-K36M, Tg(CAG-H3F3B*K37M)1Kaig
• Transgene: Tg(CAG-H3-3B*K37M)1Kaig Location: unknown
• Alliance: Tg(CAG-H3-3B*K37M)1Kaig page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-H3-3B*K37M)1Kaig expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  H3-3B (3021)

  H3f3b

  (MGI:1101768)

  expresses human H3-3B cDNA with 3' sequence encoding a FLAG tag and an internal K37M mutation

• Tg(CAG-H3-3B*K37M)1Kaig expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: Human H3-3B cDNA with 3' sequence encoding a FLAG tag and an internal K37M mutation is expressed under the control of an actin (CAG) promoter. A loxP-STOP-loxP cassette is also inserted between the promoter and expressed sequence, and suppresses expression of the human cDNA unless cre-mediated recombination removes the loxP-STOP-loxP cassette. (J:262992)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:262992 Zhuang L, et al., Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018 May 4;9(1):1796
• All: 3 reference(s)