Mldhr^em1Zhgn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mldhr^em1Zhgn
• Name: mitochondrial lactate dehydrogenase regulator; endonuclease-mediated mutation 1, Nu Zhang
• MGI ID: MGI:7612218
• Gene: Mldhr Location: unknown Genetic Position: Chr19, Syntenic
• Alliance: Mldhr^em1Zhgn page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9-mediated recombination created a 145 bp deletion. (J:303725)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mldhr Mutation: 0 strains or lines available

References

• Original: J:303725 Huang N, et al., An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism. Cell Metab. 2021 Jan 5;33(1):128-144.e9
• All: 1 reference(s)