Ntrk2^em1(cre)Bxu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ntrk2^em1(cre)Bxu
• Name: neurotrophic tyrosine kinase, receptor, type 2; endonuclease-mediated mutation 1,Baoji Xu
• MGI ID: MGI:7612056
• Synonyms: Ntrk2^2A-Cre
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^em1(cre)Bxu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Ntrk2^em1(cre)Bxu expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ntrk2 (MGI:97384)

• Mutation details: Using the CRISPR/Cas9 technique, a P2A-Cre recombinase sequence was inserted immediately before the stop codon for the full-length tropomyosin related kinase receptor B (TrkB.FL) isoform at the neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2) locus on chromosome 13. A silent mutation was also introduced into the PAM site of the sgRNA located within the 3' homology arm in the donor plasmid. (J:345865)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ntrk2 (mouse) Summary of all recombinase alleles driven by Ntrk2. Alliance mouse Ntrk2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:345865 Niu C, et al., Genetic dissection of BDNF and TrkB expression in glial cells. bioRxiv. 2023
• All: 1 reference(s)