Exoc3l^em1Mema
Endonuclease-mediated Allele Detail

Summary

• Symbol: Exoc3l^em1Mema
• Name: exocyst complex component 3-like; endonuclease-mediated mutation 1, Masatsugu Ema
• MGI ID: MGI:7612042
• Synonyms: Exoc3l^tdTomato
• Gene: Exoc3l Location: Chr8:106016556-106022733 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Exoc3l^em1Mema page

Mutation origin

• Strain of Origin: C57BL/6JCrlj

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology inserted a tdTomato cassette replacing most of exon 2 to most of exon 14 (the entire coding sequence). While tdTomato mRNA is detectable, fluorescence is undetectable indicating that expression may be low. (J:345822)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Exoc3l Mutation: 38 strains or lines available

References

• Original: J:345822 Takashima S, et al., Null mutation of exocyst complex component 3-like does not affect vascular development in mice. Exp Anim. 2024 Feb 14;73(1):93-100
• All: 1 reference(s)