Frmd5^em#Yuw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Frmd5^em#Yuw
• Name: FERM domain containing 5; endonuclease-mediated mutation, Yun Wang
• MGI ID: MGI:7611626
• Gene: Frmd5 Location: Chr2:121376010-121637568 bp, - strand Genetic Position: Chr2, 60.42 cM
• Alliance: Frmd5^em#Yuw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN technology targeting exon 6 generated two alleles, a 1-bp deletion and a 2-bp deletion, both of which resulted in a frameshift mutation and premature termination. While two lines were generated, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:345640)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frmd5 Mutation: 54 strains or lines available

References

• Original: J:345640 Lyu TJ, et al., Deficiency of FRMD5 results in neurodevelopmental dysfunction and autistic-like behavior in mice. Mol Psychiatry. 2024 Jan 16
• All: 1 reference(s)