Grp^{tm1(RNAi:Grin1)Tmnb}
Targeted Allele Detail

Summary

• Symbol: Grp^{tm1(RNAi:Grin1)Tmnb}
• Name: gastrin releasing peptide; targeted mutation 1, Toshiya Manabe
• MGI ID: MGI:7610740
• Synonyms: Grp^{tm1(GFP/miR)Tmnb}
• Gene: Grp Location: Chr18:66005891-66019667 bp, + strand Genetic Position: Chr18, 38.98 cM
• Alliance: Grp^{tm1(RNAi:Grin1)Tmnb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:345726
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Knockdown, Null/knockout, Reporter)
• Mutation: Insertion
• Grp^{tm1(RNAi:Grin1)Tmnb} involves 1 genes/genome features (Grin1) View all
• Mutation details: The targeted insertion inserted E. coli neomycin cDNA, P1 phage loxP sequence, jellyfish GFP cDNA, and mouse Grin1 miRNA sequence upstream of the translation initiation site. Recombination removed the selection cassette. (J:345726)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grp Mutation: 30 strains or lines available

References

• Original: J:345726 Goto F, et al., Gastrin-releasing peptide regulates fear learning under stressed conditions via activation of the amygdalostriatal transition area. Mol Psychiatry. 2022;27(3):1694-1703
• All: 1 reference(s)