Col1a1tm1(tetO-PHGDH)Mgvh
Targeted Allele Detail
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Symbol: |
Col1a1tm1(tetO-PHGDH)Mgvh |
Name: |
collagen, type I, alpha 1; targeted mutation 1, Matthew G Vander Heiden |
MGI ID: |
MGI:7610185 |
Synonyms: |
PHGDHtetO |
Gene: |
Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
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Alliance: |
Col1a1tm1(tetO-PHGDH)Mgvh page
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Allele Type: |
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Targeted (Inserted expressed sequence, RMCE-ready) |
Mutation: |
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Insertion
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Col1a1tm1(tetO-PHGDH)Mgvh expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
PHGDH (26227) |
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Mutation details: The targeting vector was designed to insert a human PHGDH cDNA placed downstream of a tetracycline-responsive element (TRE) promoter, and targeted via recombinase-mediated cassette exchange (RMCE) into the ubiquitously expressed collagen, type I, alpha 1 (Col1a1) gene. The targeting vector also contained a hygromycin resistance cassette.
(J:285109)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Col1a1 Mutation: |
166 strains or lines available
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Original: |
J:285109 Mattaini KR, et al., Increased PHGDH expression promotes aberrant melanin accumulation. BMC Cancer. 2019 Jul 22;19(1):723 |
All: |
2 reference(s) |
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