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Col1a1tm1(tetO-PHGDH)Mgvh
Targeted Allele Detail
Summary
Symbol: Col1a1tm1(tetO-PHGDH)Mgvh
Name: collagen, type I, alpha 1; targeted mutation 1, Matthew G Vander Heiden
MGI ID: MGI:7610185
Synonyms: PHGDHtetO
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm1(tetO-PHGDH)Mgvh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:285109
Parent Cell Line:  KH2 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, RMCE-ready)
Mutation:    Insertion
 
Col1a1tm1(tetO-PHGDH)Mgvh expresses 1 gene
 
Mutation detailsThe targeting vector was designed to insert a human PHGDH cDNA placed downstream of a tetracycline-responsive element (TRE) promoter, and targeted via recombinase-mediated cassette exchange (RMCE) into the ubiquitously expressed collagen, type I, alpha 1 (Col1a1) gene. The targeting vector also contained a hygromycin resistance cassette. (J:285109)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  166 strains or lines available
References
Original:  J:285109 Mattaini KR, et al., Increased PHGDH expression promotes aberrant melanin accumulation. BMC Cancer. 2019 Jul 22;19(1):723
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory