Fcgr4^{em1(FCGR3A)Synbl}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fcgr4^{em1(FCGR3A)Synbl}
• Name: Fc receptor, IgG, low affinity IV; endonuclease-mediated mutation 1, Synbal
• MGI ID: MGI:7607012
• Gene: Fcgr4 Location: Chr1:170846495-170857330 bp, + strand Genetic Position: Chr1, 78.53 cM
• Alliance: Fcgr4^{em1(FCGR3A)Synbl} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Fcgr4^{em1(FCGR3A)Synbl} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FCGR3A (2214)

  Fcgr4

  (MGI:2179523)

• Mutation details: Using a CRISPR/Cas9 approach, an active genetic cassette (AGC) was used to remove the endogenous mouse gene coding region and replace it with a functional human coding region under the control of the endogenous mouse promoter. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr4 Mutation: 22 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)