Fcgr3^{em1(FCGR2A)Synbl}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fcgr3^{em1(FCGR2A)Synbl}
• Name: Fc receptor, IgG, low affinity III; endonuclease-mediated mutation 1, Synbal
• MGI ID: MGI:7607011
• Synonyms: Humanized Mouse-hFcgr3
• Gene: Fcgr3 Location: Chr1:170878743-170892504 bp, - strand Genetic Position: Chr1, 78.8 cM
• Alliance: Fcgr3^{em1(FCGR2A)Synbl} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Fcgr3^{em1(FCGR2A)Synbl} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FCGR2A (2212)

  Fcgr2b	(MGI:95499)
  Fcgr3	(MGI:95500)

• Mutation details: Using a CRISPR/Cas9 approach, an active genetic cassette (AGC) was used to remove the endogenous mouse gene coding region and replace it with a functional human coding region under the control of the endogenous mouse promoter. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr3 Mutation: 29 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)