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Esm1tm1.1Ics
Targeted Allele Detail
Summary
Symbol: Esm1tm1.1Ics
Name: endothelial cell-specific molecule 1; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:7606211
Gene: Esm1  Location: Chr13:113346193-113354632 bp, + strand  Genetic Position: Chr13, 63.93 cM
Alliance: Esm1tm1.1Ics page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:344933
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP-flanked neomycin resistance cassette replaced exons 1 and 2. The neomycin selection cassette was removed via cre-mediated recombination. (J:344933)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esm1 Mutation:  17 strains or lines available
References
Original:  J:344933 Zheng X, et al., Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice. Kidney360. 2022 Dec 29;3(12):2059-2076
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory