Esm1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Esm1^tm1.1Ics
• Name: endothelial cell-specific molecule 1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7606211
• Gene: Esm1 Location: Chr13:113346193-113354632 bp, + strand Genetic Position: Chr13, 63.93 cM
• Alliance: Esm1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:344933
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin resistance cassette replaced exons 1 and 2. The neomycin selection cassette was removed via cre-mediated recombination. (J:344933)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esm1 Mutation: 17 strains or lines available

References

• Original: J:344933 Zheng X, et al., Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice. Kidney360. 2022 Dec 29;3(12):2059-2076
• All: 2 reference(s)