Chd8^em1Qrlu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chd8^em1Qrlu
• Name: chromodomain helicase DNA binding protein 8; endonuclease-mediated mutation 1, Q Richard Lu
• MGI ID: MGI:7596533
• Synonyms: Chd8^flox
• Gene: Chd8 Location: Chr14:52435608-52495237 bp, - strand Genetic Position: Chr14, 26.84 cM
• Alliance: Chd8^em1Qrlu page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate an insertion of loxP sites in intron 3 and intron 4. (J:263977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd8 Mutation: 108 strains or lines available

References

• Original: J:263977 Zhao C, et al., Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Dev Cell. 2018 Jun 18;45(6):753-768.e8
• All: 6 reference(s)