Klc3^em1Jvt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klc3^em1Jvt
• Name: kinesin light chain 3; endonuclease-mediated mutation 1, JL Vilotte
• MGI ID: MGI:7596450
• Gene: Klc3 Location: Chr7:19128362-19138029 bp, - strand Genetic Position: Chr7, 9.62 cM
• Alliance: Klc3^em1Jvt page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting exon 2 generated a 10 bp deletion. Western blot analysis confirmed the absence of protein in homozygous testes. This is line 05. (J:345392)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klc3 Mutation: 18 strains or lines available

References

• Original: J:345392 Daniel-Carlier N, et al., Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility. Biol Reprod. 2024 Jan 13;110(1):78-89
• All: 1 reference(s)