Mtfp1^tm1.2Wait
Targeted Allele Detail

Summary

• Symbol: Mtfp1^tm1.2Wait
• Name: mitochondrial fission process 1; targeted mutation 1.2, Timothy Wai
• MGI ID: MGI:7596142
• Synonyms: Mtfp1^loxP
• Gene: Mtfp1 Location: Chr11:4041481-4045431 bp, - strand Genetic Position: Chr11, 2.87 cM
• Alliance: Mtfp1^tm1.2Wait page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330965
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 2 and 3 floxed. (J:330965)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtfp1 Mutation: 16 strains or lines available

References

• Original: J:330965 Donnarumma E, et al., Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure. Nat Commun. 2022 Nov 4;13(1):6634
• All: 2 reference(s)