Ripk4^tm2.1Vmd
Targeted Allele Detail

Summary

• Symbol: Ripk4^tm2.1Vmd
• Name: receptor-interacting serine-threonine kinase 4; targeted mutation 2.1, Vishva M Dixit
• MGI ID: MGI:7595813
• Synonyms: Ripk4^loxp
• Gene: Ripk4 Location: Chr16:97543133-97564979 bp, - strand Genetic Position: Chr16, 57.63 cM
• Alliance: Ripk4^tm2.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283325
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 2. The neo cassette was removed through subsequent Flp-mediated recombination. (J:283325)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk4 Mutation: 46 strains or lines available

References

• Original: J:283325 Oberbeck N, et al., The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function. Nature. 2019 Oct;574(7777):249-253
• All: 1 reference(s)