Sspo^em1Lehm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sspo^em1Lehm
• Name: SCO-spondin; endonuclease-mediated mutation 1, Maria K Lehtinen
• MGI ID: MGI:7595634
• Synonyms: Sspo^tm1Leh
• Gene: Sspo Location: Chr6:48425163-48478184 bp, + strand Genetic Position: Chr6, 23.42 cM
• Alliance: Sspo^em1Lehm page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination using gRNAs created a 5bp deletion in exon 2 resulting a premature stop codon. (J:344687)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sspo Mutation: 222 strains or lines available

References

• Original: J:344687 Xu H, et al., SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation. Fluids Barriers CNS. 2023 Dec 5;20(1):89
• All: 1 reference(s)