Tspan15^em1Psf
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tspan15^em1Psf
• Name: tetraspanin 15; endonuclease-mediated mutation 1, Paul Saftig
• MGI ID: MGI:7594194
• Gene: Tspan15 Location: Chr10:62021175-62067030 bp, - strand Genetic Position: Chr10, 32.36 cM
• Alliance: Tspan15^em1Psf page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-mediated genome editing technology was used to generate a 104 bp deletion mutation inducing a translational stop codon in exon 2 of the gene. Immunoblot analysis confirmed the absence of protein in various tissues, including brain, heart, lung, spleen, kidney and liver. (J:345187)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspan15 Mutation: 12 strains or lines available

References

• Original: J:345187 Seipold L, et al., In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15. Cell Mol Life Sci. 2018 Sep;75(17):3251-3267
• All: 1 reference(s)