Ano1^tm1.2Mzhu
Targeted Allele Detail

Summary

• Symbol: Ano1^tm1.2Mzhu
• Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1.2, Min-Sheng Zhu
• MGI ID: MGI:7594040
• Synonyms: Tmem16a KO
• Gene: Ano1 Location: Chr7:144142286-144305711 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Ano1^tm1.2Mzhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331144
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exon 12 was deleted after cre-mediated recombination of flanking loxP sites in the germline. (J:331144)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano1 Mutation: 61 strains or lines available

References

• Original: J:331144 Yuan W, et al., Intracellular TMEM16A is necessary for myogenesis of skeletal muscle. iScience. 2022 Nov 18;25(11):105446
• All: 1 reference(s)