Cabcoco1^em1Gaof
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cabcoco1^em1Gaof
• Name: ciliary associated calcium binding coiled-coil 1; endonuclease-mediated mutation 1, Fei Gao
• MGI ID: MGI:7594038
• Synonyms: Cabcoco1^-, Cabcoco1-knockout
• Gene: Cabcoco1 Location: Chr10:68266783-68377726 bp, - strand Genetic Position: Chr10, 35.4 cM, cytoband B5.1
• Alliance: Cabcoco1^em1Gaof page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of all exons of the gene. Western blotting and immunofluorescence staining confirmed the complete absence of protein expression in the testes of homozygous mutant males. (J:345163)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cabcoco1 Mutation: 22 strains or lines available

References

• Original: J:345163 Wang M, et al., CCDC189 affects sperm flagellum formation by interacting with CABCOCO1. Natl Sci Rev. 2023 Sep;10(9):nwad181
• All: 1 reference(s)