Ets1^em2Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ets1^em2Cya
• Name: Ets proto-oncogene 1, transcription factor; endonuclease-mediated mutation 2, Cyagen Biosciences
• MGI ID: MGI:7583641
• Synonyms: Ets1^em1flox
• Gene: Ets1 Location: Chr9:32547517-32669116 bp, + strand Genetic Position: Chr9, 17.97 cM
• Alliance: Ets1^em2Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 7~8 will be selected as conditional knockout region (cKO region). (J:326541, J:357517)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ets1 Mutation: 28 strains or lines available

References

• Original: J:357517 Cao Y, et al., ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population. Carcinogenesis. 2024 Oct 10;45(10):745-758
• All: 2 reference(s)