Apoe^{em8(APOE*)Msasn}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Apoe^{em8(APOE*)Msasn}
• Name: apolipoprotein E; endonuclease-mediated mutation 8, Michael Sasner
• MGI ID: MGI:7581968
• Synonyms: APOE4s3
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^{em8(APOE*)Msasn} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Humanized sequence)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 inserted sequences into the apolipoprotein E (Apoe) gene on chromosome 7 that contains a conditional by inversion (COIN) cassette containing APOE4 human genomic sequence exons 2-4 with and 1500bp of the 3' UTR. The APOE4 sequence contains a loxP site downstream of exon 3, a polyA signal downstream of exon 4, followed by a lox2272 site APOE3 exon 4 in reverse orientation, a loxP site and a lox2272 site followed by the APOE4 3' UTR. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 164 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)