Sptan1^em1Fliu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sptan1^em1Fliu
• Name: spectrin alpha, non-erythrocytic 1; endonuclease-mediated mutation 1, Feng Liu
• MGI ID: MGI:7581873
• Gene: Sptan1 Location: Chr2:29855572-29921463 bp, + strand Genetic Position: Chr2, 20.93 cM, cytoband B
• Alliance: Sptan1^em1Fliu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/cas9 mediated recombination using guide RNAs introduced loxP sites surrounding exons 6 - 8. (J:345069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sptan1 Mutation: 130 strains or lines available

References

• Original: J:345069 Yao Q, et al., Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling. Mol Neurobiol. 2022 Jan;59(1):386-404
• All: 1 reference(s)