Myo3b^tm1Pgg
Targeted Allele Detail

Summary

• Symbol: Myo3b^tm1Pgg
• Name: myosin IIIB; targeted mutation 1, Peter G Gillespie
• MGI ID: MGI:7581078
• Synonyms: Myo3b^-
• Gene: Myo3b Location: Chr2:69869470-70259542 bp, + strand Genetic Position: Chr2, 41.05 cM
• Alliance: Myo3b^tm1Pgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236347
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Conventional gene targeting eliminated exons 3 and 4, replacing them with a neomycin-resistance gene cassette conjugated to LacZ. A premature stop codon was introduced in exon 5. RT-PCR analysis of inner-ear mRNA demonstrated the expected truncated band in homozygous mutant mice. (J:236347)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo3b Mutation: 85 strains or lines available

References

• Original: J:236347 Ebrahim S, et al., Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like. Nat Commun. 2016 Mar 01;7:10833
• All: 1 reference(s)