Espn^tm1Pgg
Targeted Allele Detail

Summary

• Symbol: Espn^tm1Pgg
• Name: espin; targeted mutation 1, Peter G Gillespie
• MGI ID: MGI:7581076
• Synonyms: Espn-1^-
• Gene: Espn Location: Chr4:152204788-152236828 bp, - strand Genetic Position: Chr4, 82.9 cM, cytoband E1
• Alliance: Espn^tm1Pgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236347
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Modified isoform(s), Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was deleted via conventional gene targeting. A long isoform of the encoded protein is not expressed, but short ESPN isoforms arising from an alternative translation start site in exon 6 are unaffected. (J:236347)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Espn Mutation: 37 strains or lines available

References

• Original: J:236347 Ebrahim S, et al., Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like. Nat Commun. 2016 Mar 01;7:10833
• All: 1 reference(s)