Thrb^em1Few
Endonuclease-mediated Allele Detail

Summary

• Symbol: Thrb^em1Few
• Name: thyroid hormone receptor beta; endonuclease-mediated mutation 1, Fredric E Wondisford
• MGI ID: MGI:7580552
• Synonyms: Thrb2^S101A
• Gene: Thrb Location: Chr14:4431611-4809435 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
• Alliance: Thrb^em1Few page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of serine with alanine at position 101 (S101A) of isoform 2. (J:344938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thrb Mutation: 41 strains or lines available

References

• Original: J:344938 Minakhina S, et al., Thyroid hormone receptor phosphorylation regulates acute fasting-induced suppression of the hypothalamic-pituitary-thyroid axis. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2107943118
• All: 2 reference(s)