Hoxa2^em1Krum
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hoxa2^em1Krum
• Name: homeobox A2; endonuclease-mediated mutation 1, Robb Krumlauf
• MGI ID: MGI:7579143
• Synonyms: a2KO
• Gene: Hoxa2 Location: Chr6:52139397-52141811 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa2^em1Krum page

Mutation origin

• Strain of Origin: (CBA/CaJ C57BL/10)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, to mutate a 7 bp region (5'-AGGCCATG-3'), including part of the start codon of Hoxa2, by deleting 2 bp of the start codon and converting it into an XhoI site (5'-CTCGAG-3'). (J:344634)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxa2 Mutation: 19 strains or lines available

References

• Original: J:344634 Pushel I, et al., Specification of axial identity by Hoxa2 distinguishes between a phenotypic and molecular ground state in mouse cranial neural crest cells. bioRxiv. 2021
• All: 1 reference(s)