Clec1a^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Clec1a^tm1.1Arte
• Name: C-type lectin domain family 1, member a; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:7578822
• Synonyms: MelLec KO
• Gene: Clec1a Location: Chr6:129403647-129428963 bp, - strand Genetic Position: Chr6, 63.32 cM
• Alliance: Clec1a^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312602
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked puromycin selection cassette replaced exons 1-5 of the gene. These exons correspond to the cytoplasmic tail, transmembrane, stalk and part of the CRD region of the encoded protein. The selection cassette was susequently removed via transient cre expression. (J:312602)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec1a Mutation: 17 strains or lines available

References

• Original: J:312602 Stappers MHT, et al., Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature. 2018 Mar 15;555(7696):382-386
• All: 2 reference(s)