Cacna1a^em1Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cacna1a^em1Lutzy
• Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; endonuclease-mediated mutation 1, Cathy Lutz
• MGI ID: MGI:7577429
• Synonyms: Cacna1a^S220L
• Gene: Cacna1a Location: Chr8:85065268-85366875 bp, + strand Genetic Position: Chr8, 40.95 cM
• Alliance: Cacna1a^em1Lutzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR/cas9 endonuclease-mediated genome editing, the missense S220L (TCA to CTG, serine to leucine) variant was introduced in the exon 5 of the Cacna1a gene. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1a Mutation: 115 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)