Psen1tm1.1(PSEN1)Mdk
Targeted Allele Detail
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Symbol: |
Psen1tm1.1(PSEN1)Mdk |
Name: |
presenilin 1; targeted mutation 1.1, Michael D Koob |
MGI ID: |
MGI:7576962 |
Synonyms: |
PSEN1-GR |
Gene: |
Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
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Alliance: |
Psen1tm1.1(PSEN1)Mdk page
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Germline Transmission: |
Earliest citation of germline transmission:
J:101977
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Parent Cell Line: |
PRX-B6N (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Psen1tm1.1(PSEN1)Mdk expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
PSEN1 (5663) |
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Mutation details: The targeting vector is designed to insert a 106 kb (Chr14:73121400 - 73227703) fragment of the human PSEN1 in place of Chr12:83730110 - 83793335 of the mouse Psen1 gene. The construct includes an loxP-flanked neomycin selection cassette. In addition, there is also a PSEN1-DT (non-coding antisense RNA) in the human genome segment. The insertion disrupts Psen1 transcription. The neomycin cassette was removed by transient expression of cre.
(J:101977)
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Original: |
J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017; |
All: |
1 reference(s) |
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