Snca^{tm3.1(SNCA*E46K)Mdk}
Targeted Allele Detail

Summary

• Symbol: Snca^{tm3.1(SNCA*E46K)Mdk}
• Name: synuclein, alpha; targeted mutation 3.1, Michael D Koob
• MGI ID: MGI:7576960
• Synonyms: E46K SNCA-GR
• Gene: Snca Location: Chr6:60708559-60806839 bp, - strand Genetic Position: Chr6, 29.15 cM
• Alliance: Snca^{tm3.1(SNCA*E46K)Mdk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Snca^{tm3.1(SNCA*E46K)Mdk} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  E46K

• Mutation details: The targeting vector is designed to insert a 158 kb (Chr4:89707185 - 89865027) fragment of the human SNCA carrying the E46K (glutamic acid to lysine) mutation in exon 3 in place of Chr6:60683985 - 60848702 of the mouse Snca gene. The genomic sequences are from human assembly GRCh38.p14 and the mouse assembly GRCm39. The construct includes an loxP-flanked neomycin selection cassette. In addition, there is also a SNCA non-coding antisense RNA in the human genome segment. The insertion disrupts Snca transcription. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snca Mutation: 34 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)