Tardbp^{tm1.1(TARDBP)Mdk}
Targeted Allele Detail

Summary

• Symbol: Tardbp^{tm1.1(TARDBP)Mdk}
• Name: TAR DNA binding protein; targeted mutation 1.1, Michael D Koob
• MGI ID: MGI:7576944
• Synonyms: TARDBP-GR
• Gene: Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
• Alliance: Tardbp^{tm1.1(TARDBP)Mdk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Tardbp^{tm1.1(TARDBP)Mdk} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: The targeting vector is designed to insert a 65 kb (Chr1: 10989074 - 11054422) fragment of the human TARDBP (TAR DNA binding protein) in place of Chr4:148679229 - 148723697 of the mouse Tardbp gene. The genomic sequences are from human assembly GRCh38.p14 and the mouse assembly GRCm39. The insertion disrupts Tardbp transcription. The construct includes an loxP-flanked neomycin selection cassette. In addition, there is also a TARDBP (non-coding antisense RNA) in the human genome segment. Transient cre-mediated recombination removed the neo cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tardbp Mutation: 60 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)