Htt^{tm1(HTT*)Chdi}
Targeted Allele Detail

Summary

• Symbol: Htt^{tm1(HTT*)Chdi}
• Name: huntingtin; targeted mutation 1, David Howland
• MGI ID: MGI:7576912
• Synonyms: Htt Q107
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^{tm1(HTT*)Chdi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The allele was designed to replace mouse huntingtin (Htt) exon 1 with a human HTT exon 1 sequence containing a polyglutamine expansion comprised of a pure CAG expansion ~(CAG)109CAACAG. The knock-in (KI) was accomplished by homologous recombination in C57BL/6NTac-derived ES cells.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 179 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)